New work reveals a key signal transduction pathway through which nitric oxide (NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin-mediated degradation of nuclear target proteins.
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Benhar, M., Stamler, J. A central role for S-nitrosylation in apoptosis. Nat Cell Biol 7, 645–646 (2005). https://doi.org/10.1038/ncb0705-645
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DOI: https://doi.org/10.1038/ncb0705-645
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