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May the force be with you: Myosin-X in phagocytosis

Nature Cell Biology volume 4, pages E169E171 (2002) | Download Citation

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Engulfment of pathogens by phagocytosis requires the coordination of actin assembly and progressive 'zippering' of pseudopodial membranes around the particle. Recent work shows that Myosin-X, which binds phosphatidylinositol-3-OH kinase (PI(3)K) products through its pleckstrin homology (PH) domains, is required for phagocytosis, thereby providing a molecular basis for the function of PI(3)K in pseudopod extension.

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Author information

Affiliations

  1. Philippe Chavrier is at the Institut Curie – Section de Recherche, 26 rue d'Ulm, 75005 Paris, France Philippe.Chavrier@curie.fr

    • Philippe Chavrier

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DOI

https://doi.org/10.1038/ncb0702-e169

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