Local regulation of protein translation is essential for synaptic plasticity. MicroRNA-mediated alteration in expression of an enzyme that regulates the palmitoylation of a specific synaptic protein determines dendritic spine size.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hering, H. & Sheng, M. Nature Rev. Neurosci. 2, 880–888 (2001).
Bramham, C. R. & Wells, D. G. Nature Rev. Neurosci. 8, 776–789 (2007).
Siegel, G. et al. Nature Cell Biol. 11, 705–716 (2009).
Bartel, D. P. Cell 116, 281–297 (2004).
Lee, R. C. et al. Cell 75, 843–854 (1993).
Ambros, V. Nature 431, 350–355 (2004).
Kosik, K. S. Nature Rev. Neurosci. 7, 911–920 (2006).
Schratt, G. M. et al. Nature 439, 283–289 (2006).
Meister, G. et al. RNA 10, 544–550 (2004).
Husseini Ael, D. et al. Cell 108, 849–863 (2002).
Kang, R. et al. Nature 456, 904–909 (2008).
Yeh, D. C. et al. J. Biol. Chem. 274, 33148–33154 (1999).
Bhattacharyya, R. & Wedegaertner, P. B. J. Biol. Chem. 275, 14992–14999 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carrel, D., Firestein, B. MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines. Nat Cell Biol 11, 681–682 (2009). https://doi.org/10.1038/ncb0609-681
Issue Date:
DOI: https://doi.org/10.1038/ncb0609-681
This article is cited by
-
Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth
Molecular Neurobiology (2019)