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MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines

Local regulation of protein translation is essential for synaptic plasticity. MicroRNA-mediated alteration in expression of an enzyme that regulates the palmitoylation of a specific synaptic protein determines dendritic spine size.

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Figure 1: RNA-138 may control spine size in response to synaptic activity by regulating APT1-mediated palmitoylation of Gα13.

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Carrel, D., Firestein, B. MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines. Nat Cell Biol 11, 681–682 (2009). https://doi.org/10.1038/ncb0609-681

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