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Transcription RINGs in repair

A recent study has shown that the Ssl1 subunit of the general transcription/DNA repair factor TFIIH contains ubiquitin ligase activity that is dependent on a RING domain. The RING domain is required for transcription of a subset of yeast genes that are involved in DNA damage repair, thus uncovering a novel ubiquitination-associated function for TFIIH in the repair process.

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Figure 1: The multifunctional general transcription factor, TFIIH.


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Osley, M. Transcription RINGs in repair. Nat Cell Biol 7, 553–555 (2005).

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