Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Transcription RINGs in repair

A recent study has shown that the Ssl1 subunit of the general transcription/DNA repair factor TFIIH contains ubiquitin ligase activity that is dependent on a RING domain. The RING domain is required for transcription of a subset of yeast genes that are involved in DNA damage repair, thus uncovering a novel ubiquitination-associated function for TFIIH in the repair process.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The multifunctional general transcription factor, TFIIH.

References

  1. Zurita, M. & Merino, C. Trends Genet. 19, 578–584 (2003).

    CAS  Article  Google Scholar 

  2. Svejstrup, J. Nature Rev. Mol. Cell Biol. 3, 21–29 (2002).

    CAS  Article  Google Scholar 

  3. De Laat, W., Jaspers, N. & Hoeijmakers, J. Genes Dev. 13, 768–785 (1999).

    CAS  Article  Google Scholar 

  4. Keogh, M.-C., Cho, E.-J., Podolny, V. & Buratowski, S. Mol. Cell. Biol. 22, 1288–1297 (2002).

    CAS  Article  Google Scholar 

  5. Svejstrup, J., Vichi, P. & Egly, J. M. Trends Biochem. Sci. 21, 346–350 (1996).

    CAS  Article  Google Scholar 

  6. Takagi, Y. et al. Mol. Cell 18, 237–243 (2005).

    CAS  Article  Google Scholar 

  7. Joazeiro, C. & Weissman, A. Cell 102, 549–552 (2000).

    CAS  Article  Google Scholar 

  8. Pickart, C. Cell 116, 181–190 (2004).

    CAS  Article  Google Scholar 

  9. Kellenberger, E. et al. J. Biol. Chem. (in the press).

  10. Chang, W. & Kornberg, R. Cell 102, 609–613 (2000).

    CAS  Article  Google Scholar 

  11. Schultz, P. et al. Cell 102, 599–607 (2000).

    CAS  Article  Google Scholar 

  12. Muratami, M. & Tansey, W. P. Nature Rev. Mol. Cell Biol. 4, 1–10 (2003).

    Google Scholar 

  13. Beaudenon, S. et al. Mol. Cell. Biol. 19, 6972–6979 (1999).

    CAS  Article  Google Scholar 

  14. Kao, C. et al. Genes Dev. 18, 184–195 (2004).

    CAS  Article  Google Scholar 

  15. Takagi, Y. et al. J. Biol. Chem. 278, 43897–43900 (2003).

    CAS  Article  Google Scholar 

  16. Giglia-Mari, G. et al. Nature Genet. 36, 714–719 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Osley, M. Transcription RINGs in repair. Nat Cell Biol 7, 553–555 (2005). https://doi.org/10.1038/ncb0605-553

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0605-553

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing