Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Historical Perspective
  • Published:

Merging cultures in the study of membrane traffic

Abstract

Membrane and organelle assembly has emerged as a dominant theme in cell biology of the twenty-first century. Current approaches and questions have been formulated as a result of numerous historical threads that together weave a complex picture of cellular compartments. The confluence of morphologic, genetic and biochemical approaches laid the foundations for study in this area, and they continue to strengthen our understanding of this essential aspect of cell structure and function.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Morphology of the endoplasmic reticulum and structure of the translocation channel.

Similar content being viewed by others

References

  1. Sabatini, D.D. et al. J. Cell Biol. 17, 19–58 (1963).

    Article  CAS  Google Scholar 

  2. de Duve, C. Science 189, 186–194 (1975).

    Article  Google Scholar 

  3. Palade, G. Science 189, 347–358 (1975).

    Article  CAS  Google Scholar 

  4. Painter, R. et al. Proc. Natl Acad. Sci. USA 70, 1649–1653 (1973).

    Article  CAS  Google Scholar 

  5. Orci, L. et al. Cell 42, 671–681 (1985).

    Article  CAS  Google Scholar 

  6. Helenius, A. et al. J. Cell Biol. 84, 404–420 (1980).

    Article  CAS  Google Scholar 

  7. Goldstein, J.L. et al. Nature 279, 679–685 (1979).

    Article  CAS  Google Scholar 

  8. Boulan, E. & Sabatini, D. Proc. Natl Acad. Sci. USA 75, 5071–5075 (1978).

    Article  Google Scholar 

  9. Matter, K. & Mellman, I. Curr. Opin. Cell Biol. 6, 545–554 (1994).

    Article  CAS  Google Scholar 

  10. Folsch, H. et al. Cell 99, 191–198 (1999).

    Article  Google Scholar 

  11. Orci, L. et al. Cell 46, 171–184 (1986).

    Article  CAS  Google Scholar 

  12. Orci, L. et al. Nature 364, 732–734 (1993).

    Article  CAS  Google Scholar 

  13. Lippincott-Schwartz, J. et al. Ann. Rev. Cell Dev. Biol. 16, 557–589 (2000).

    Article  CAS  Google Scholar 

  14. Emr, S. et al. Cell 23, 79–88 (1981).

    Article  CAS  Google Scholar 

  15. Ito, K. et al. Cell 32, 789–797 (1983).

    Article  CAS  Google Scholar 

  16. Deshaies, R. & Schekman, R. J. Cell Biol. 105, 633–645 (1987).

    Article  CAS  Google Scholar 

  17. Mathes, W. et al. EMBO J. 13, 3973–3982 (1994).

    Article  Google Scholar 

  18. Novick, P. et al. Cell 25, 461–469 (1981).

    Article  CAS  Google Scholar 

  19. Bankaitis, V. et al. Proc. Natl Acad. Sci. USA 83, 9075–9079 (1986).

    Article  CAS  Google Scholar 

  20. Rothman, T. & Stevens, T. Cell 47, 1041–1051 (1986).

    Article  CAS  Google Scholar 

  21. Chvatchko, Y. et al. Cell 46, 355–364 (1986).

    Article  CAS  Google Scholar 

  22. Salminen, A. & Novick, P. Cell 49, 527–538 (1987).

    Article  CAS  Google Scholar 

  23. Schu, P. et al. Science 260, 88–91 (1993).

    Article  CAS  Google Scholar 

  24. Rose, M. et al. Cell 57, 1211–1221 (1989).

    Article  CAS  Google Scholar 

  25. Vogel, J. et al. J. Cell Biol. 110, 1885–1895 (1990).

    Article  CAS  Google Scholar 

  26. Lewis, M. et al. Cell 61, 1359–1363 (1990).

    Article  CAS  Google Scholar 

  27. Kosaka, T. & Ikeda, K. J. Cell Biol. 97, 499–507 (1983).

    Article  CAS  Google Scholar 

  28. Marsh, M. & McMahon, H.T. Science 185, 215–220 (1999).

    Article  Google Scholar 

  29. Bonifacino, J.S. & Dell'Angelica, E.C. J. Cell Biol. 145, 923–926 (1999).

    Article  CAS  Google Scholar 

  30. Kornfeld, S. & Mellman, I. Annu. Rev. Cell Biol. 5, 483–525 (1989).

    Article  CAS  Google Scholar 

  31. Zhang, B. et al. Nature Genet. 34, 220–225 (2003).

    Article  CAS  Google Scholar 

  32. Jones, B. et al. Nature Genet. 34, 29–31 (2003).

    Article  CAS  Google Scholar 

  33. Redman, C. & Sabatini, D. Proc. Natl Acad. Sci. USA 56, 608–615 (1966).

    Article  CAS  Google Scholar 

  34. Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 835–851 (1975).

    Article  CAS  Google Scholar 

  35. Brundage, L. et al. Cell 6, 649–657 (1990).

    Article  Google Scholar 

  36. Görlich, D. & Rapoport, T. Cell 75, 615–630 (1993).

    Article  Google Scholar 

  37. Roth, T. & Porter, K. J. Cell Biol. 20, 313–332 (1964).

    Article  CAS  Google Scholar 

  38. Letourneur, F. et al. Cell 79, 1199–1207 (1994).

    Article  CAS  Google Scholar 

  39. Vale, R. et al. Cell 42, 39–50 (1985).

    Article  CAS  Google Scholar 

  40. Block, M. et al. Proc. Natl Acad. Sci. USA 85, 7852–7856 (1988).

    Article  CAS  Google Scholar 

  41. Söllner, T. et al. Nature 362, 318–324 (1993).

    Article  Google Scholar 

  42. Barlowe, C. et al. Cell 77, 895–907 (1994).

    Article  CAS  Google Scholar 

  43. Bennett, M. et al. Science 257, 255–259 (1992).

    Article  CAS  Google Scholar 

  44. McNew, J. et al. Nature 407, 153–159 (2000).

    Article  CAS  Google Scholar 

  45. Kaiser, C. & Schekman, R. Cell 61, 723–733 (1990).

    Article  CAS  Google Scholar 

  46. Wickner, W. EMBO J. 21, 1241–1247 (2002).

    Article  CAS  Google Scholar 

  47. Martin, T.F. Neuron 34, 9–12 (2002).

    Article  CAS  Google Scholar 

  48. Van den Berg et al. Nature 427, 36–44 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schekman, R. Merging cultures in the study of membrane traffic. Nat Cell Biol 6, 483–486 (2004). https://doi.org/10.1038/ncb0604-483

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0604-483

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing