Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Round-trip ticket: recycling to the plasma membrane requires RME-1

Nature Cell Biology volume 3, pages E133–E135 (2001)Cite this article

The endosomal system includes distinct endocytic compartments where decisions are made that determine the destinations of extracellular and plasma membrane materials that have been internalized. A new family of proteins has been found that governs the exit of material from one of these endocytic organelles, the endosomal recycling compartment (ERC).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Compartments within the endosomal system.
Figure 2: The RME-1 cycle.

References

  1. Mukherjee, S., Ghosh, R. N. & Maxfield, F. R. Endocytosis. Physiol. Rev. 77, 759–803 (1997).

    Article  CAS  Google Scholar 

  2. Yamashiro, D. J., Tycko, B., Fluss, S. R. & Maxfield, F. R. Cell 37, 789–800 (1984).

    Article  CAS  Google Scholar 

  3. Zuk, P. A. & Elferink, L. A. J. Biol. Chem. 274, 22303–12 (1999).

    Article  CAS  Google Scholar 

  4. Ullrich, O., Reinsch, S., Urbe, S., Zerial, M. & Parton, R. G. J. Cell Biol. 135, 913–24 (1996).

    Article  CAS  Google Scholar 

  5. Prekeris, R., Klumperman, J., Chen, Y. A. & Scheller, R. H. J. Cell Biol. 143, 957–71 (1998).

    Article  CAS  Google Scholar 

  6. Daro, E., van der Sluijs, P., Galli, T. & Mellman, I. Proc. Natl Acad. Sci. USA 93, 9559–64 (1996).

    Article  CAS  Google Scholar 

  7. Lin, S. X., Grant, B., Hirsh, D. & Maxfield, F. R. Nature Cell Biol. 3, 567–572 (2001).

    Article  CAS  Google Scholar 

  8. Grant, B. et al. Nature Cell Biol. 3, 573–579 (2001).

    Article  CAS  Google Scholar 

  9. Saraste, M., Sibbald, P. R. & Wittinghofer, A. Trends Biochem. Sci. 15, 430–4 (1990).

    Article  Google Scholar 

  10. Santolini, E., Salcini, A. E., Kay, B. K., Yamabhai, M. & Di Fiore, P. P. Exp. Cell Res. 253, 186–209 (1999).

    Article  CAS  Google Scholar 

  11. Pohl, U. et al. Genomics 63, 255–62 (2000).

    Article  CAS  Google Scholar 

  12. Haider, N. B. et al. Gene 240, 227–32 (1999).

    Article  CAS  Google Scholar 

  13. Torrisi, M. R. et al. Mol. Biol. Cell 10, 417–34 (1999).

    Article  CAS  Google Scholar 

  14. Grant, B. & Hirsh, D. Mol. Biol. Cell 10, 4311–26 (1999).

    Article  CAS  Google Scholar 

  15. Fire, A. et al. Nature 391, 806–11 (1998).

    Article  CAS  Google Scholar 

  16. Chen, L. & Davis, N. G. J. Cell Biol. 151, 731–8 (2000).

    Article  CAS  Google Scholar 

  17. Wiederkehr, A., Avaro, S., Prescianotto-Baschong, C., Haguenauer-Tsapis, R. & Riezman, H. J. Cell Biol. 149, 397–410 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Beverly Wendland is in the Department of Biology, Johns Hopkins University, 3400 N Charles street, Baltimore, 21218, Maryland, USA

    Beverly Wendland

Authors
  1. Beverly Wendland
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wendland, B. Round-trip ticket: recycling to the plasma membrane requires RME-1. Nat Cell Biol 3, E133–E135 (2001). https://doi.org/10.1038/35078592

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35078592

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing