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Different site, different splice

Nature Cell Biology volume 2, pages E98–E100 (2000)Cite this article

Abstract

The MKK3/6–p38 pathway has been found to induce the relocalization of premessenger-RNA splicing factors from the nucleus to the cytoplasm. This represents the first physiological mechanism that alters the nuclear ratios of splicing factors and modulates alternative splice-site choice in vivo.

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Figure 1: The ratio of the splicing factors SF2/ASF relative to hnRNP A1 controls alternative 5′ splice-site choice.

References

  1. van der Houven van Oort, W. et al.J. Cell Biol. 149, 307–316 (2000).

    Article  Google Scholar 

  2. Hanke, J. et al.Trends Genet. 15, 389–390 (1999).

    Article  CAS  Google Scholar 

  3. Mayeda, A. & Krainer, A. R. Cell 68, 365–375 (1992).

    Article  CAS  Google Scholar 

  4. Cáceres, J. F., Stamm, S., Helfman, D. M. & Krainer, A. R. Science 265, 1706–1709 (1994).

    Article  Google Scholar 

  5. Yang, X. et al.Proc. Natl Acad. Sci. USA 91, 6924–6928 (1994).

    Article  CAS  Google Scholar 

  6. Turpin, P., Ossareh–Nazari, B. & Dargemont, C. FEBS Lett. 452, 82–86 (1999).

    Article  CAS  Google Scholar 

  7. Hanamura, A. et al.RNA J. 4, 430–444 (1998).

    CAS  Google Scholar 

  8. Misteli, T. J. Cell Sci. 113, 1841–1849 (2000).

    CAS  PubMed  Google Scholar 

  9. Duncan, P. I., Stojdl, D. F., Marius, R. M. & Bell, J. C. Mol. Cell Biol. 17, 5996–6001 (1997).

    Article  CAS  Google Scholar 

  10. Cramer, P., Pesce, C. G., Baralle, F. E. & Kornblihtt, A. R. Proc. Natl Acad. Sci. USA 94, 11456–11460 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. the National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Tom Misteli

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  1. Tom Misteli
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Misteli, T. Different site, different splice. Nat Cell Biol 2, E98–E100 (2000). https://doi.org/10.1038/35014091

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  • DOI: https://doi.org/10.1038/35014091

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