Abstract
Most proteins that are secreted or expressed on a cell surface are synthesized on membrane polysomes and enter the endoplasmic reticulum (ER) as unfolded polypeptide chains. A complex series of interactions with resident enzymes and molecular chaperones ensure that these proteins are folded and assembled to achieve their correct tertiary structures before being transported to the Golgi and along the secretory pathway. However, the mechanism by which properly folded molecules are sorted from incompletely or improperly folded proteins and from the resident proteins that guide this process remains unclear.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hammond, C. & Helenius, A. Curr.Opin.Cell Biol. 7, 523–529 (1995).
Nehls, S. et al. Nature Cell Biol. 2, 288– 295 (2000).
Lodish, H. F., Kong, N., Snider, M. & Strous, G. J. Nature 304, 80–83 (1983).
Wieland, F. T., Gleason, M. L., Serafini, T. A. & Rothman, J. E. Cell 50, 289–300 ( 1987).
Haas, I. G. & Wabl, M. Nature 306, 387–389 (1983).
Hendershot, L., Bole, D., Kohler, G. & Kearney, J. F. J. Cell Biol. 104, 761–767 ( 1987).
Munro, S. & Pelham, H. R. Cell 48, 899–907 (1987).
Lewis, M. J., Sweet, D. J. & Pelham, H. R. Cell 61, 1359– 1363 (1990).
Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S. & Klausner, R. D. Cell 56, 801–813 ( 1989).
Balch, W. E., McCaffery, J. M., Plutner, H. & Farquhar, M. G. Cell 76, 841–852 ( 1994).
Schimmoller, F. et al. EMBO J. 14, 1329–1339 (1995).
Nichols, W. C. et al. Cell 93, 61–70 (1998).
Reddy, P., Sparvoli, A., Fagioli, C., Fassina, G. & Sitia, R. EMBO J. 15, 2077–2085 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hendershot, L. Giving protein traffic the green light. Nat Cell Biol 2, E105–E106 (2000). https://doi.org/10.1038/35014100
Issue Date:
DOI: https://doi.org/10.1038/35014100