COPII-coated vesicles drive protein export from the endoplasmic reticulum (ER), although the regulation of this event, both spatially and kinetically, remains unclear. TFG is now defined as a factor that modulates recruitment of the coat and links ER sequestration of kinases to oncogenesis.
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Pagant, S., Miller, E. Transforming ER exit: protein secretion meets oncogenesis. Nat Cell Biol 13, 525–526 (2011). https://doi.org/10.1038/ncb0511-525
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DOI: https://doi.org/10.1038/ncb0511-525