Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.
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Barrero, M., Belmonte, J. iPS cells forgive but do not forget. Nat Cell Biol 13, 523–525 (2011). https://doi.org/10.1038/ncb0511-523
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DOI: https://doi.org/10.1038/ncb0511-523
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Establishment of transgene-free induced pluripotent stem cells reprogrammed from human stem cells of apical papilla for neural differentiation
Stem Cell Research & Therapy (2012)