SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of β1-integrins and loss of invasive potential.
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Juliano, R. SCAI blocks MAL-evolent effects on cancer cell invasion. Nat Cell Biol 11, 540–542 (2009). https://doi.org/10.1038/ncb0509-540
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DOI: https://doi.org/10.1038/ncb0509-540