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Sliding doors: clathrin-coated pits or caveolae?

Nature Cell Biology volume 5, pages 382–384 (2003)Cite this article

Some cell-surface receptors activate downstream signal transduction pathways not only from the cell surface but also from endosomes, suggesting that signalling pathways can be regulated by compartmentalization. A further twist is that different internalization routes seem to predetermine whether transforming growth factor β (TGF-β) receptors will trigger a signalling response or be degraded.

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Figure 1: Entry routes and pathways of the TGF-β receptor.

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Authors and Affiliations

  1. Department of Biochemistry, Sciences II, 30 quai E. Ansermet, Geneva, 4, CH-1211, Switzerland

    Michela Felberbaum-Corti & Jean Gruenberg

  2. Department of Genetics and Microbiology, CMU, 1, rue Michel-Servet, Geneva, 4, CH-1211, Switzerland

    Françoise Gisou Van Der Goot

Authors
  1. Michela Felberbaum-Corti
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  2. Françoise Gisou Van Der Goot
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  3. Jean Gruenberg
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Felberbaum-Corti, M., Van Der Goot, F. & Gruenberg, J. Sliding doors: clathrin-coated pits or caveolae?. Nat Cell Biol 5, 382–384 (2003). https://doi.org/10.1038/ncb0503-382

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