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Dam1 complexes go it alone on disassembling microtubules

Nature Cell Biology volume 10, pages 379–381 (2008)Cite this article

Kinetochores maintain a mechanical grip on disassembling microtubule plus ends, possibly through a 16-member Dam1 ring that acts as a sliding clamp. It turns out, however, that a ring is not required for maintaining grip: individual Dam1 complexes in vitro can diffuse on the microtubule lattice and track shortening microtubule tips.

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Figure 1: A biased-diffusion model for tip-tracking of single Dam1 complexes on depolymerizing microtubule ends.

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Authors and Affiliations

  1. Melissa K. Gardner and David J. Odde are in the Department of Biomedical Engineering, University of Minnesota, 312 Church Street SE, 7-132 Hasselmo Hall, Minneapolis, Minnesota 55455, USA. oddex002@umn.edu,

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Gardner, M., Odde, D. Dam1 complexes go it alone on disassembling microtubules. Nat Cell Biol 10, 379–381 (2008). https://doi.org/10.1038/ncb0408-379

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