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Bicarbonate secretion: it takes two to tango

Nature Cell Biology volume 6, pages 292–294 (2004)Cite this article

New research reveals a reciprocal regulation between the CFTR chloride channel, implicated in cystic fibrosis, and several members of the SLC26 family of chloride-bicarbonate exchangers. These findings provide new insights into the mechanism of epithelial bicarbonate and fluid transport and may lead to better treatments for cystic fibrosis and congenital chloride diarrhoeas.

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Figure 1: Interactions between CFTR and SLC26 transporters.

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  1. the Institute of Cell and Molecular Biosciences, University Medical School, Newcastle upon Tyne, NE2 4HH, UK

    Michael A. Gray

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  1. Michael A. Gray
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Gray, M. Bicarbonate secretion: it takes two to tango. Nat Cell Biol 6, 292–294 (2004). https://doi.org/10.1038/ncb0404-292

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