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A helicase that gets Oskar's message across

Messenger RNA localization is a common way of targeting proteins to their site of function. This process is dependent on RNA signals that are interpreted by trans-acting factors. A putative RNA helicase and translational initiation factor is now shown to form a conserved complex, important for localization of oskar mRNA in Drosophila melanogaster and RNA surveillance in human cells.

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Figure 1: Ribonucleoprotein sorting during fly oogenesis.
Figure 2: eIF4AIII, Btz and Mago-Y14 may be recruited at distinct stages.


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Davis, I. A helicase that gets Oskar's message across. Nat Cell Biol 6, 285–287 (2004).

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