Apoptosis is a carefully orchestrated series of events that allows cells to be eliminated without damaging their neighbours. Regulation is essential, as too much apoptosis can contribute to neurodegenerative disorders, whereas too little can result in cancer. Two reports in this issue now demonstrate that Ku70, a protein previously shown to function in DNA repair, has an important role in regulating apoptotic events.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Penninger, J.M. & Kroemer, G. Nature Cell Biol. 5, 97–99 (2003).
Cory, S. & Adams, J.M. Nature Rev. Cancer 2, 647–656 (2002).
Makin, G.W. et al. EMBO J. 20, 6306–6315 (2001).
Hardwick, J.M. & Polster, B.M. Mol. Cell 10, 963–965 (2002).
Epand, R.F., Martinou, J.-C., Fornallaz-Malhauser, M., Hughes, D.W. & Epand, R.M. J. Biol. Chem. 277, 32632–32639 (2002).
Scorrano, L. et al. Dev. Cell 2, 55–67 (2002).
Terradillos, O., Montessuit, S., Huang, D.C. & Martinou, J.-C. FEBS Lett. 522, 29–34 (2002).
Roucou, X. & Martinou, J.-C. Cell Death Differ. 8, 875–877 (2001).
Desagher, S. & Martinou, J.-C. Trends Cell Biol. 10, 369–377 (2000).
Sawada, M. et al. Nature Cell Biol. 5, 320–329 (2003).
Sawada, M., Hayes, P. & Matsuyama, S. Nature Cell Biol. 5, 352–357 (2003).
Xu, Q. & Reed, J.C. Mol. Cell 1, 337–346 (1998).
Goping, I. et al. J. Cell Biol. 143, 207–215 (1998).
Cartron, P.-F. et al. J. Biol. Chem. (in the press).
Kim, S.H. et al. Cancer Res. 59, 4012–4017 (1999).
Roucou, X., Montessuit, S., Antonsson, B. & Martinou, J.-C. Biochem. J. 368, 915–921 (2002).
Kuwana, T. et al. Cell 111, 331–342 (2002).
Khanna, K.K. & Jackson, S.P. Nature Genet. 27, 247–254 (2001).
Lakin, N.D. & Jackson, S.P. Oncogene 18, 7644–7655 (1999).
Brown, K.D. et al. J. Biol. Chem. 275, 6651–6656 (2000).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nothwehr, S., Martinou, JC. A retention factor keeps death at bay. Nat Cell Biol 5, 281–282 (2003). https://doi.org/10.1038/ncb0403-281
Issue Date:
DOI: https://doi.org/10.1038/ncb0403-281
