Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-β). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-β type II receptor (TβRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-β and PTH signalling in vivo.
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Atfi, A., Baron, R. PTH battles TGF-β in bone. Nat Cell Biol 12, 205–207 (2010). https://doi.org/10.1038/ncb0310-205
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DOI: https://doi.org/10.1038/ncb0310-205