Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Prions remodel gene expression in yeast

Nature Cell Biology volume 11, pages 241–243 (2009)Cite this article

Epigenetic mechanisms participate in the regulation of gene transcription in eukaryotes. Two studies in yeast have revealed an additional mechanism for controlling global gene transcription that is based on an inherited self-perpetuating change in the conformation of two different components of key transcriptional regulatory complexes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genetic screen for the yeast [OCT+] prion.
Figure 2: Glutamine/asparagine-rich regions in Cyc8, Swi1 and Tup1.

References

  1. Bird, A. Nature 447, 396–398 (2007).

    Article  CAS  Google Scholar 

  2. Du, Z., Park, K. W., Yu, H., Fan, Q. & Li, L. Nature Genet. 40, 460–465 (2008).

    Article  CAS  Google Scholar 

  3. Patel, B. K., Gavin-Smyth, J. & Liebman, S. W. Nature Cell Biol. 11, 344–349 (2009).

    Article  CAS  Google Scholar 

  4. Prusiner, S. B., Scott, M. R., DeArmound, S. J. & Cohen, F. E. Cell 93, 337–348 (1998).

    Article  CAS  Google Scholar 

  5. Wickner, R. B. Science 264, 566–569 (1994).

    Article  CAS  Google Scholar 

  6. Peterson, C. L., Dingwall, A. & Scott, M. P. Proc. Natl Acad. Sci. USA 91, 2905–2908 (1994).

    Article  CAS  Google Scholar 

  7. Smith, R. L. & Johnson, A. D. Trends Biochem. Sci. 25, 325–330 (2000).

    Article  CAS  Google Scholar 

  8. Derkatch, I. L., Bradley, M. E., Hong, J. Y. & Liebman, S. W. Cell 106, 171–182 (2001).

    Article  CAS  Google Scholar 

  9. Tuite, M. F. Cell 100, 289–292 (2000).

    Article  CAS  Google Scholar 

  10. Tanaka, M. & Weissman, J. S. Methods Enzymol. 412, 185–200 (2006).

    Article  CAS  Google Scholar 

  11. Roberts, B. T. & Wickner, R. B. Genes Dev. 17, 2083–2087 (2003).

    Article  CAS  Google Scholar 

  12. Eaglestone, S. S., Cox, B. S. & Tuite, M. F. EMBO J. 18, 1974–1981 (1999).

    Article  CAS  Google Scholar 

  13. True, H. L. & Lindquist, S. L. Nature 407, 477–483 (2000).

    Article  CAS  Google Scholar 

  14. Tyedmers, J., Madariaga, M. L. & Lindquist, S. PLoS Biol. 6, e294 (2008).

    Article  Google Scholar 

  15. Nakayashiki, T., Kurtzman, C. P., Edskes, H. K. & Wickner, R. B. Proc. Natl Acad. Sci. USA 102, 10575–10580 (2005).

    Article  CAS  Google Scholar 

  16. Hammer, N. D., Schmidt, J. C. & Chapman, M. R. Proc. Natl Acad. Sci. USA 104, 12494–12499 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biosciences, Mick F. Tuite and Brian S. Cox are in the Kent Fungal Group, University of Kent, Canterbury, Kent CT2 7NJ, UK. m.f.tuite@kent.ac.uk,

    Mick F. Tuite & Brian S. Cox

Authors
  1. Mick F. Tuite
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian S. Cox
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tuite, M., Cox, B. Prions remodel gene expression in yeast. Nat Cell Biol 11, 241–243 (2009). https://doi.org/10.1038/ncb0309-241

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0309-241

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing