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Stressed marrow: FoxOs stem tumour growth

Nature Cell Biology volume 9, pages 251–253 (2007)Cite this article

Although the molecular machinery controlling aging has been well studied in lower organisms, it is unclear whether these mechanisms are conserved in mammals. A recent study supports a role for an evolutionarily conserved transcriptional pathway in maintaining the unlimited lifespan of haematopoietic stem cells.

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Figure 1: Regulation of stem-cell fate by FoxO transcription factors.

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Authors and Affiliations

  1. Paul J. Coffer is in the Deparment of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands. P.J.Coffer@umcutrecht.nl;,

    Paul J. Coffer

  2. Boudewijn M. T. Burgering is in the Laboratory of Physiological Chemistry, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. B.M.T.Burgering@umcutrecht.nl,

    Boudewijn M. T. Burgering

Authors
  1. Paul J. Coffer
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  2. Boudewijn M. T. Burgering
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Coffer, P., Burgering, B. Stressed marrow: FoxOs stem tumour growth. Nat Cell Biol 9, 251–253 (2007). https://doi.org/10.1038/ncb0307-251

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