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Repressed by a NuRD

Nature Cell Biology volume 8, pages 212–214 (2006)Cite this article

Embryonic stem (ES) cells deficient in Mbd3, a component of the nucleosome remodelling complex (NuRD), exhibit LIF-independent self-renewal and a restricted potential to differentiate. As such, it is likely that NuRD is required for ES cell pluripotency, and represents a potential link between maintaining the undifferentiated state and the capacity to differentiate.

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Figure 1: The NuRD repression complex.
Figure 2: NuRD/Mbd3-mediated ES cell fate.

References

  1. Boiani, M. & Schöler, H. R. Nature Rev. Mol. Cell Biol. 6, 872–884 (2005).

    Article  CAS  Google Scholar 

  2. Boyer, L. A. et al. Cell 122, 1–10 (2005).

    Article  Google Scholar 

  3. Kaji, K. et al. Nature Cell Biol. 8, 285–292 (2006).

    Article  CAS  Google Scholar 

  4. Ahringer, J. Trends Genet. 16, 351–356 (2000).

    Article  CAS  Google Scholar 

  5. Bowen, N. J. et al. Biochim. Biophys. Acta 1677, 52–57 (2004).

    Article  CAS  Google Scholar 

  6. Zhang, Y. et al. Genes Dev. 13, 1924–1935 (1999).

    Article  CAS  Google Scholar 

  7. Hendrich, B. et al. Genes Dev. 15, 710–723 (2001).

    Article  CAS  Google Scholar 

  8. Niwa, H. et al. Nature Genet. 24, 372–376 (2000).

    Article  CAS  Google Scholar 

  9. Bortvin, A. et al. BMC Dev. Biol. 4, 10.1186/1471-213X-4-2 (2004).

  10. Epping M. T. et al. Cell 122, 835–847 (2005).

    Article  CAS  Google Scholar 

Download references

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  1. ES Cell International Pte Ltd, 11 Biopolis Way, #05-06, Helios, 138667, Singapore

    Jeremy M. Crook, N. Ray Dunn & Alan Colman

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  1. Jeremy M. Crook
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  2. N. Ray Dunn
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  3. Alan Colman
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Crook, J., Dunn, N. & Colman, A. Repressed by a NuRD. Nat Cell Biol 8, 212–214 (2006). https://doi.org/10.1038/ncb0306-212

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