Mutations in either of two polycystin genes can cause kidney failure, but controversy remains regarding the cellular localization and function of the protein products. Polycystin-2 may be a calcium release channel located within the endoplasmic reticulum (ER), and yet may be physically linked to polycystin-1 in the surface membrane.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ashcroft, F. in Ion Channels and Disease (Academic Press, 2000).
Somlo, S., & Ehrlich, B. Curr. Biol. 11, R356–360 (2001).
Koulen, P. et al. Nature Cell Biol. 4, 191–197 (2002).
Gonzalez-Perrett, S. et al. Proc. Natl Acad. Sci. USA 98, 1182–1187 (2001).
Hanaoka, K. et al. Nature 408, 990–994 (2000).
Vassilev, P. M. et al. Biochem. Biophys. Res. Commun. 282, 341–350 (2001).
Cai, Y. et al. J. Biol. Chem. 274, 28557–28565 (1999).
Tsiokas, L., Kim, E., Arnould, T., Sukhatme, V. P. & Walz, G. Proc. Natl Acad. Sci. USA 94, 6965–6970 (1997).
Tsiokas, L. et al. Proc. Natl Acad. Sci. USA 96, 3934–3939 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cahalan, M. The ins and outs of polycystin-2 as a calcium release channel. Nat Cell Biol 4, E56–E57 (2002). https://doi.org/10.1038/ncb0302-e56
Issue Date:
DOI: https://doi.org/10.1038/ncb0302-e56
This article is cited by
-
Subcellular localization and trafficking of polycystins
Pflügers Archiv - European Journal of Physiology (2005)
