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The cell biology of neuronal navigation

Nature Cell Biology volume 3, pages E81–E88 (2001)Cite this article

Abstract

Morphogenesis of the nervous system requires the directed migration of postmitotic neurons to designated locations in the nervous system and the guidance of axon growth cones to their synaptic targets. Evidence suggests that both forms of navigation depend on common guidance molecules, surface receptors and signal transduction pathways that link receptor activation to cytoskeletal reorganization. Future challenges remain not only in identifying all the components of the signalling pathways, but also in understanding how these pathways achieve signal amplification and adaptation—two essential cellular processes for neuronal navigation.

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Figure 1: Amplification and adaptation during growth cone navigation in a gradient of guidance signals.
Figure 2: The interwoven network of signalling molecules that link guidance receptors with the cytoskeletal rearrangement underlying directed neuronal motility.

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Acknowledgements

We thank G. Ming for help with the manuscript. H-j.S. is supported by a fellowship from the Howard Hughes Medical Institute. The work on growth-cone guidance in the authors' laboratory was supported by a grant from the National Institutes of Health.

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  1. Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, 92037 , California, USA

    Hong-jun Song

  2. Department of Molecular and Cell Biology, University of California, Berkeley, 94720, California, USA

    Mu-ming Poo

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Correspondence to Hong-jun Song or Mu-ming Poo.

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Song, Hj., Poo, Mm. The cell biology of neuronal navigation. Nat Cell Biol 3, E81–E88 (2001). https://doi.org/10.1038/35060164

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