New tricks for an old dog?

The Arp2/3 complex affects the rate of actin polymerization and promotes cellular actin assembly. Recent work has shown that cortactin is capable of stimulating the actin-nucleating activity of the Arp2/3 complex. In addition, more insight has been gained into how new actin-filament branches are formed and how actin patches in yeast are assembled.

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Figure 1: Infections with Listeria, Shigella and vaccinia virus induce rearrangement of the actin cytoskeleton and formation of dynamic, pathogen-tipped actin tails (reviewed in ref. 15).

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Zettl, M., Way, M. New tricks for an old dog?. Nat Cell Biol 3, E74–E75 (2001). https://doi.org/10.1038/35060152

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