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Neurofilaments run sprints not marathons

Abstract

In neurons, cytoskeletal proteins are transported from where they are made — the cell body — along the axons, but it has long been disputed whether they are transported as subunits or polymers. A new analysis of neurofilament movement may help to resolve the controversy.

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Figure 1: Two models for neurofilament movement along neuronal axons.

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Brady, S. Neurofilaments run sprints not marathons. Nat Cell Biol 2, E43–E45 (2000). https://doi.org/10.1038/35004071

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