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The pRb–Cdh1–p27 autoamplifying network

Nature Cell Biology volume 9, pages 137138 (2007) | Download Citation

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In proliferating cells, the SCFSkp2ubiquitin ligase targets the CDK inhibitor p27 for proteolysis. A study now shows that the tumour suppressor pRb promotes the APC/CCdh1–mediated degradation of Skp2, resulting in the accumulation of p27.

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Affiliations

  1. Patricia G. Santamaría and Michele Pagano are in the Department of Pathology, New York University School of Medicine and NYU Cancer Institute, MSB 599, 550 First Avenue, New York, NY 10016, USA. michele.pagano@med.nyu.edu

    • Patricia G. Santamaría
    •  & Michele Pagano

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DOI

https://doi.org/10.1038/ncb0207-137

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