Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.
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References
Sukharev, S. & Corey, D. P. Science's STKE 219, re4 (2004).
Corey, D. P. et al. Nature 10.1038/nature03066 (2004).
Maroto, R. et al. Nature Cell Biol. 7, 179–185 (2005).
Clapham, D. E. Nature 426, 517–524 (2003).
Nilius, B. Science's STKE 243, pe36 (2004).
Story, G. M. et al. Cell 112, 819–829 (2003).
Jordt, S. -E. et al. Nature 427, 260–265 (2004).
Christensen, O. Nature 330, 66–68 (1987).
Wes, P. D. et al. Proc. Natl Acad. Sci. USA 92, 9652–9656 (1995).
Hamill, O. P. & Martinac, B. Physiol. Revs 81, 685–740 (2001).
Voets, T. et al. Nature 430, 748–754 (2004).
Rosado, J. A. & Sage, S. O. Biochem. J. 356, 191–198 (2001).
Vaca, L. & Sampieri, A. J. Biol. Chem. 277, 42178–42187 (2002).
Mori, T. et al. J. Exp. Med. 195, 673–681 (2002).
Chen, J. & Barritt, G. J. Biochem. J. 373, 327–336 (2003).
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Barritt, G., Rychkov, G. TRPs as mechanosensitive channels. Nat Cell Biol 7, 105–107 (2005). https://doi.org/10.1038/ncb0205-105
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DOI: https://doi.org/10.1038/ncb0205-105
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