Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein

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Figure 1: Inhibition of kinesin activity or expression of D2K44E inhibits release of p75–GFP from the Golgi/TGN after release from a block at 20 °C.
Figure 2: Post-Golgi trafficking of p75–GFP-containing vesicles and tubules after release from a 20 °C temperature block is mediated by kinesin and dynamin.

References

  1. 1

    Hirokawa, N. Science 279, 519–526 ( 1996).

    Article  Google Scholar 

  2. 2

    Seiler, S., Nargang, F. E., Steinberg, G. & Schliwa, M. EMBO J. 16, 3025–3034 ( 1997).

    CAS  Article  Google Scholar 

  3. 3

    Thyberg, J. & Moskalewski, S. Exp. Cell Res. 246 , 263–279 (1999).

    CAS  Article  Google Scholar 

  4. 4

    Wacker, I. et al. J. Cell Sci. 110, 1453– 1463 (1997).

    CAS  PubMed  Google Scholar 

  5. 5

    Cole, N. B., Sciaky, N., Marotta, A., Song, J. & Lipincott-Schwartz, J. Mol. Biol. Cell 7, 631– 650 (1996).

    CAS  Article  Google Scholar 

  6. 6

    Storrie, B. et al. J. Cell Biol. 143, 1505– 1521 (1998).

    CAS  Article  Google Scholar 

  7. 7

    Rodionov, V. I., Gyoeva, F. K. & Gelfand, V. I. Proc. Natl Acad. Sci. USA 88, 4956–4960 (1991).

    CAS  Article  Google Scholar 

  8. 8

    Rodionov, V. I. et al. J. Cell Biol. 123, 1811– 1820 (1993).

    CAS  Article  Google Scholar 

  9. 9

    Gyoeva, F. K. & Gelfand, V. I. Nature 353, 445–453 (1991).

    CAS  Article  Google Scholar 

  10. 10

    Hollenbeck, P. J. & Swanson, J. A. Nature 346, 864–866 (1990).

    CAS  Article  Google Scholar 

  11. 11

    Ingold, A. L., Cohn, S. A. & Scholey, J. M. J. Cell Biol. 107, 2657– 2667 (1988).

    CAS  Article  Google Scholar 

  12. 12

    Cao, H., Garcia, F. & McNiven, M. A. Mol. Biol. Cell 9, 2595– 2609 (1998).

    CAS  Article  Google Scholar 

  13. 13

    Hirschberg, K. et al. J. Cell Biol. 143, 1485– 1503 (1998).

    CAS  Article  Google Scholar 

  14. 14

    Toomre, D., Keller, P., White, J., Olivo, J-C. & Simons, K. J. Cell Sci. 112, 21– 33 (1999).

    CAS  PubMed  Google Scholar 

  15. 15

    Jones, S. M., Howell, K. E., Henley, J., Cao, H. & McNiven, M. A. Science 279, 573–576 (1998).

    CAS  Article  Google Scholar 

  16. 16

    Altschuler, Y. et al. J. Cell Biol. 143, 1871– 1881 (1998).

    CAS  Article  Google Scholar 

  17. 17

    Kasai, K., Shin, H-W., Shinotsuka, C., Murakami, K. & Nakyama, K. J. Biochem. 125, 780–789 (1999).

    CAS  Article  Google Scholar 

  18. 18

    Luby-Phelps, K., Castle, P. E., Taylor, D. L. & Lanni, F. Proc. Natl Acad. Sci. USA 84, 4910– 4913 (1987).

    CAS  Article  Google Scholar 

  19. 19

    Finger, F. P. & Novick, P. J. Cell Biol. 142, 609–612 (1998).

    CAS  Article  Google Scholar 

  20. 20

    Muesch, A., Cohen, D. & Rodriguez-Boulan, E. J. Cell Biol. 138, 291– 306 (1997).

    Article  Google Scholar 

  21. 21

    Balch, W. E., McCaffery, J. M., Plutner, H. & Farquhar, M. G. Cell 76, 841–852 ( 1994).

    CAS  Article  Google Scholar 

  22. 22

    Scales, S. J., Pepperkok, R. & Kreis, T. E. Cell 90, 1137– 1148 (1997).

    CAS  Article  Google Scholar 

  23. 23

    Presley, J. F. et al. Nature 389, 81–85 (1997).

    CAS  Article  Google Scholar 

  24. 24

    Bloom, G. S. & Goldstein, L. B. J. J. Cell Biol. 140, 1277–1280 (1998).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

This work was supported in part by a grant from the NIH and by a Jules and Doris Stein professorship of the Research to Prevent Blindness Foundation (to E.R.-B.) and by an NIH NRSA fellowship (to G.K.).

Correspondence and requests for materials should be addressed to E.R.-B.

Supplementary information is available on Nature Cell Biology’s World-Wide Web site (http://cellbio.nature.com) or as paper copy from the London editorial office of Nature Cell Biology.

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Correspondence to Enrique Rodriguez-Boulan.

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Kreitzer, G., Marmorstein, A., Okamoto, P. et al. Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein. Nat Cell Biol 2, 125–127 (2000). https://doi.org/10.1038/35000081

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  • DOI: https://doi.org/10.1038/35000081

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