Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Membrane repair redux: redox of MG53

Most cells can rapidly repair extensive tears in their plasma membrane, a response dependent on extracellular calcium. Entry of extracellular oxidants through a membrane disruption oxidizes and thus activates a newly discovered membrane repair protein, MG53, in skeletal muscle cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model for membrane repair.


  1. Clarke, M. S., Khakee, R. & McNeil, P. L. J. Cell Sci. 106, 121–133 (1993).

    CAS  PubMed  Google Scholar 

  2. Bansal, D. et al. Nature 423, 168–172 (2003).

    Article  CAS  Google Scholar 

  3. Steinhardt, R. A., Bi, G. & Alderton, J. M. Science 263, 390–393 (1994).

    Article  CAS  Google Scholar 

  4. Verkhratsky, A. Subcell. Biochem. 45, 465–480 (2007).

    Article  CAS  Google Scholar 

  5. Heilbrunn, L. V. Proc. Am. Philos. Soc. LXIX, 295–301 (1930).

    Google Scholar 

  6. Cai, C. et al. Nature Cell Biol. 11, 56–64 (2008).

    Article  Google Scholar 

  7. McNeil, P. L. & Kirchhausen, T. Nature Rev. Mol. Cell Biol. 6, 499–505 (2005).

    Article  CAS  Google Scholar 

  8. McNeil, A. K., Rescher, U., Gerke, V. & McNeil, P. L. J. Biol. Chem. 281, 35202–35207 (2006).

    Article  CAS  Google Scholar 

  9. Bansal, D. & Campbell, K. P. Trends Cell Biol. 14, 206–213 (2004).

    Article  CAS  Google Scholar 

  10. Bi, G. Q. et al. J. Cell Biol. 138, 999–1008 (1997).

    Article  CAS  Google Scholar 

  11. Mellgren, R. L., Zhang, W., Miyake, K. & McNeil, P. L. J. Biol. Chem. 282, 2567–2575 (2007).

    Article  CAS  Google Scholar 

  12. Clarke, M. S., Caldwell, R. W., Chiao, H., Miyake, K. & McNeil, P. L. Circ. Res. 76, 927–934 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

McNeil, P. Membrane repair redux: redox of MG53. Nat Cell Biol 11, 7–9 (2009).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing