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Redox rescues virus from ER trap

Nature Cell Biology volume 10, pages 9–11 (2008)Cite this article

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

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Figure 1: ERp57 and low calcium are involved in SV40 pentamer dissociation.

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Authors and Affiliations

  1. Christoph J. Burckhardt & Urs F. Greber are at the Institute of Zoology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. ufgreber@zool.uzh.ch,

    Christoph J. Burckhardt & Urs F. Greber

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  1. Christoph J. Burckhardt
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  2. Urs F. Greber
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Burckhardt, C., Greber, U. Redox rescues virus from ER trap. Nat Cell Biol 10, 9–11 (2008). https://doi.org/10.1038/ncb0108-9

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