Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family. The discovery of Spir-like proteins in bacteria indicates that pathogens have adopted this mechanism to manipulate the host actin cytoskeleton.
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Quinlan, M., Kerkhoff, E. Actin nucleation: bacteria get in-Spired. Nat Cell Biol 10, 13–15 (2008). https://doi.org/10.1038/ncb0108-13
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DOI: https://doi.org/10.1038/ncb0108-13
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