Regulating actin dynamics through cofilin dephosphorylation is the role of a newly identified phosphatase, chronophin, a member of the haloacid dehalogenase (HAD) superfamily. Chronophin, the second cofilin phosphatase to be identified, has high phosphoprotein specificity towards cofilin, but curiously it was also discovered independently as a pyridoxal phosphate (vitamin B6) phosphatase.
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Wiggan, O., Bernstein, B. & Bamburg, J. A phosphatase for cofilin to be HAD. Nat Cell Biol 7, 8–9 (2005). https://doi.org/10.1038/ncb0105-8
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DOI: https://doi.org/10.1038/ncb0105-8
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