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Cyclin E at the centre of an identity crisis

Nature Cell Biology volume 7, pages 3–5 (2005)Cite this article

Some Drosophila neural progenitor cells generate segment-specific lineages in the thorax versus the abdomen. The basis for these differences is the differential expression of Cyclin E. Cyclin E functions downstream of the homeotic genes and largely independently of its role in proliferation to autonomously specify thoracic identity.

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Figure 1: Cell-fate determination in the NB6-4 neuroblast lineage of Drosophila embryos.

References

  1. Berger, C. et al. Nature Cell Biol. 7, 56–62 (2005).

    Article  CAS  Google Scholar 

  2. Li, L. & Vaessin, H. Genes Dev. 14, 147–151 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Roegiers, F., Younger-Shepherd, S., Jan, L. Y. & Jan, Y. N. Proc. Natl Acad. Sci. USA 98, 14469–14474 (2001).

    Article  CAS  Google Scholar 

  4. Tio, M., Udolph, G., Yang, X. & Chia, W. Nature 409, 1063–1067 (2001).

    Article  CAS  Google Scholar 

  5. Berdnik, D. & Knoblich, J. A. Curr. Biol. 12, 640–647 (2002).

    Article  CAS  Google Scholar 

  6. Griffiths, R. L. & Hidalgo, A. EMBO J. 23, 2440–2450 (2004).

    Article  CAS  Google Scholar 

  7. Doe, C. Q., Chu-LaGraff, Q., Wright, D. M. & Scott, M. P. Cell 65, 451–464 (1991).

    Article  CAS  Google Scholar 

  8. Vaessin, H. et al. Cell 67, 941–953 (1991).

    Article  CAS  Google Scholar 

  9. Jones, B. W., Fetter, R. D., Tear, G. & Goodman, C. S. Cell 82, 1013–1023 (1995).

    Article  CAS  Google Scholar 

  10. Hosoya, T., Takizawa, K., Nitta, K. & Hotta, Y. Cell 82, 1025–1036 (1995).

    Article  CAS  Google Scholar 

  11. Lewis, E. B. Int. J. Dev. Biol. 42, 403–415 (1998).

    CAS  PubMed  Google Scholar 

  12. Richardson, H. E., O'Keefe, L. V., Reed, S. I. & Saint, R. Development 119, 673–690 (1993).

    CAS  PubMed  Google Scholar 

  13. Knoblich, J. A. et al. Cell 77, 107–120 (1994).

    Article  CAS  Google Scholar 

  14. de Nooij, J. C., Letendre, M. A. & Hariharan, I. Cell 87, 1237–1247 (1996).

    Article  CAS  Google Scholar 

  15. Lane, M. E. et al. Cell 87, 1225–1235 (1996).

    Article  CAS  Google Scholar 

  16. Du, W., Vidal, M., Xie, J. -E. & Dyson, N. Genes Dev. 10, 1206–1218 (1996).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, 117604, Singapore

    William Chia

  2. the Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore

    Sergei N. Prokopenko

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  1. William Chia
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  2. Sergei N. Prokopenko
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Chia, W., Prokopenko, S. Cyclin E at the centre of an identity crisis. Nat Cell Biol 7, 3–5 (2005). https://doi.org/10.1038/ncb0105-3

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