Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lipid pickup and delivery

Nature Cell Biology volume 6, pages 15–16 (2004)Cite this article

Intracellular organelles have specific lipid and protein compositions. Although great progress has been made concerning the mechanisms that govern the transport of proteins between organelles, little information is available about the mechanisms of inter-organellar lipid transport. New work identifies a protein that specifically transports ceramide, a precursor of sphingolipid synthesis, between intracellular organelles.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: CERT domains function in ceramide transport.
Figure 2: Model arrangement for various enzymes of ceramide synthesis and transport.

References

  1. Simons, K. & Ikonen, E. Nature 387, 569–572 (1997).

    Article  CAS  Google Scholar 

  2. Guillas, I. et al. EMBO J. 20, 2655–2665 (2001).

    Article  CAS  Google Scholar 

  3. Schorling, S., Vallee, B., Barz, W.P., Riezman, H. & Oesterhelt, D. Mol. Biol. Cell 12, 3417–3427 (2001).

    Article  CAS  Google Scholar 

  4. Ternes, P., Franke, S., Zahringer, U., Sperling, P. & Heinz, E. J. Biol. Chem. 277, 25512–25518 (2002).

    Article  CAS  Google Scholar 

  5. Hanada, K. et al. Nature DOI:10.1038/nature02240 (2004).

  6. Funakoshi, T., Yasuda, S., Fukasawa, M., Nishijima, M. & Hanada, K. J. Biol. Chem. 275, 29938–29945 (2000).

    Article  CAS  Google Scholar 

  7. Funato, K. & Riezman, H. J. Cell Biol. 155, 949–959 (2001).

    Article  CAS  Google Scholar 

  8. Fukasawa, M., Nishijima, M. & Hanada, K. J. Cell Biol. 144, 673–685 (1999).

    Article  CAS  Google Scholar 

  9. Raya, A. et al. J. Biol. Chem. 275, 40392–40399 (2000).

    Article  CAS  Google Scholar 

  10. Levine, T.P. & Munro, S. Curr. Biol. 12, 695–704 (2002).

    Article  CAS  Google Scholar 

  11. Kallen, C.B. et al. J. Biol. Chem. 273, 26285–26288 (1998).

    Article  CAS  Google Scholar 

  12. Tsujishita, Y. & Hurley, J.H. Nature Struct. Biol. 7, 408–414 (2000).

    Article  CAS  Google Scholar 

  13. Akeroyd, R., Moonen, P., Westerman, J., Puyk, W.C. & Wirtz, K.W. Eur. J. Biochem. 114, 385–391 (1981).

    Article  CAS  Google Scholar 

  14. Trotter, P.J., Wu, W.I., Pedretti, J., Yates, R. & Voelker, D.R. J. Biol. Chem. 273, 13189–13196 (1998).

    Article  CAS  Google Scholar 

  15. Huitema, K., van den Dikkenberg, J., Brouwers, J. & Holthuis, J. EMBO J. (in the press).

  16. Ladinsky, M.S., Mastronarde, D.N., McIntosh, J.R., Howell, K.E. & Staehelin, L.A. J. Cell Biol. 144, 1135–1149 (1999).

    Article  CAS  Google Scholar 

  17. Van Tiel, C.M., Luberto, C., Snoek, G.T., Hannun, Y.A. & Wirtz, K.W. Biochem J. 346, 537–543 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Geneva, Geneva, 4, CH-1211, Switzerland

    Howard Riezman

  2. Institute of Biomembranes, Utrecht University, Utrecht, 3584 CH, The Netherlands

    Gerrit van Meer

Authors
  1. Howard Riezman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerrit van Meer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Riezman, H., van Meer, G. Lipid pickup and delivery. Nat Cell Biol 6, 15–16 (2004). https://doi.org/10.1038/ncb0104-15

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0104-15

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing