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Complexity and specificity of integrin signalling

Abstract

The α-subunits of integrins — transmembrane adhesion proteins — associate with particular transmembrane and cytoplasmic proteins, providing a mechanism for the activation of specific intracellular signalling pathways by individual integrins.

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Figure 1: The major signalling pathways activated by integrins through their α-subunits.

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Giancotti, F. Complexity and specificity of integrin signalling. Nat Cell Biol 2, E13–E14 (2000). https://doi.org/10.1038/71397

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