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Uninhibited antibiotic target discovery via chemical genetics

A combination of high-throughput screening and multicopy suppression identifies bacterial targets and resistance mechanisms of novel antimicrobials.

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Figure 1: Multicopy suppression in a high-throughput screen for novel antimicrobial compounds.

Bob Crimi

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Poole, K. Uninhibited antibiotic target discovery via chemical genetics. Nat Biotechnol 22, 1528–1529 (2004). https://doi.org/10.1038/nbt1204-1528

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