In this issue, Fu et al. describe a microfabricated fluorescence-activated cell sorter (μFACS) that can sort micron-sized latex beads and bacterial cells (p. 1109 and p. 1061). The device is a silicone elastomer chip fabricated by soft lithography, with control over the fluidics systems that will allow cells to be sorted after observing them for a long time. The μFACS could provide a low cost, disposable alternative to conventional FACS, and has the potential for integration with other microfluidic systems on a chip.