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Nuclear Hormone Receptors as Targets for New Drug Discovery

Nature Biotechnology volume 11, pages 12561261 (1993) | Download Citation

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Abstract

There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e. cAMP), and those that utilize internal, cytoplasmic or nuclear receptors (intracellular receptors) which upon activation by hormones interact directly with DNA and alter the genetic program of a cell. This review focuses on the mechanism of action of these intracellular receptors and discusses how such an understanding is expected to facilitate the discovery of new therapeutic agents.

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Author notes

    • Donald P. McDonnell

    Corresponding author.

Affiliations

  1. Department of Molecular Biology, Ligand Pharmaceuticals Inc., 11149 N. Torrey Pines Road, San Diego, CA 92037.

    • Donald P. McDonnell
    • , Elisabetta Vegeto
    •  & Martin A. G. Gleeson

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DOI

https://doi.org/10.1038/nbt1193-1256

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