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In silico research in the era of cloud computing

Snapshots of computer systems that are stored and shared 'in the cloud' could make computational analyses more reproducible.

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Figure 1: Layers of reproducible computing in the cloud.


  1. Gentleman, R. Stat. Appl. Genet. Mol. Biol. 4, Article 2 (2005).

  2. Gil, Y. et al. Computer 40, 24–32 (2007).

    Article  Google Scholar 

  3. Barker, A. & van Hemert, J. in Parallel Processing and Applied Mathematics (eds. Wyrzykowski, R., Dongarra, J., Karczewski, K. & Wasniewski, J.) 746–753 (Springer; 2008).

    Book  Google Scholar 

  4. Reich, M. et al. Nat. Genet. 38, 500–501 (2006).

    Article  CAS  Google Scholar 

  5. Hull, D. et al. Nucleic Acids Res. 34, W729–W732 (2006).

    Article  CAS  Google Scholar 

  6. De Roure, D., Goble, C. & Stevens, R. Future Gener. Comput. Syst. 25, 561–567 (2009).

    Article  Google Scholar 

  7. Mesirov, J.P. Science 327, 415–416 (2010).

    Article  CAS  Google Scholar 

  8. Ball, C.A., Sherlock, G. & Brazma, A. Nat. Biotechnol. 22, 1179–1183 (2004).

    Article  CAS  Google Scholar 

  9. Brooksbank, C. & Quackenbush, J. OMICS 10, 94–99 (2006).

    Article  CAS  Google Scholar 

  10. Wiley, H.S. & Michaels, G.S. Nat. Biotechnol. 22, 1037–1038 (2004).

    Article  CAS  Google Scholar 

  11. Lynch, C. Nature 455, 28–29 (2008).

    Article  CAS  Google Scholar 

  12. Bateman, A. & Wood, M. Bioinformatics 25, 1475 (2009).

    Article  CAS  Google Scholar 

  13. Nelson, M.R. Science 324, 1656–1657 (2009).

    Article  CAS  Google Scholar 

  14. Osterweil, L.J., Clarke, L.A. & Ellison, A.M. Science 325, 1622 (2009).

    Article  CAS  Google Scholar 

  15. Schwab, M., Karrenbach, M. & Claerbout, J. Comput. Sci. Eng. 2, 61–67 (2000).

    Article  Google Scholar 

  16. Wagener, J., Spjuth, O., Willighagen, E.L. & Wikberg, J.E. BMC Bioinformatics 10, 279 (2009).

    Article  Google Scholar 

  17. Merali, Z. & Giles, J. Nature 435, 1010–1011 (2005).

    Article  CAS  Google Scholar 

  18. Anonymous. Nature 462, 252 (2009).

  19. Gu, Y. & Grossman, R.L. Eng. Sci. 367, 2429–2445 (2009).

    Google Scholar 

  20. Langille, M.G. & Eisen, J.A. PLoS ONE 5, e10071 (2010).

    Article  Google Scholar 

  21. Stein, L.D. Genome Biol. 11, 207 (2010).

    Article  Google Scholar 

  22. Langmead, B., Schatz, M.C., Lin, J., Pop, M. & Salzberg, S.L. Genome Biol. 10, R134 (2009).

    Article  Google Scholar 

  23. Schatz, M.C. Bioinformatics 25, 1363–1369 (2009).

    Article  CAS  Google Scholar 

  24. Giardine, B. et al. Genome Res. 15, 1451–1455 (2005).

    Article  CAS  Google Scholar 

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J.T.D. is supported by the National Library of Medicine Biomedical Informatics Training Grant (T15 LM007033) and A.J.B. is supported by the National Institute for General Medical Sciences (R01 GM079719). We thank D. Singh for valuable discussion regarding cloud-computing technology.

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Correspondence to Atul J Butte.

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Dudley, J., Butte, A. In silico research in the era of cloud computing. Nat Biotechnol 28, 1181–1185 (2010).

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