Connecting genes, drugs and diseases

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A large-scale chemical genetic approach for systematically linking gene expression profiles with compounds and phenotypes offers promise for both basic and applied biomedical research.

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Figure 1: Conceptual generalization of the strategy in Lamb et al.1

References

  1. 1

    Lamb, J. et al. Science 313, 1929–1935 (2006).

  2. 2

    Hieronymus, H. et al. Cancer Cell 10, 321–330 (2006).

  3. 3

    Wei, G. et al. Cancer Cell 10, 331–342 (2006).

  4. 4

    Paull, K.D. et al. J. Natl. Cancer Inst. 81, 1088–1092 (1989).

  5. 5

    Weinstein, J.N. et al. Science 258, 447–451 (1992).

  6. 6

    Holbeck, S.L. Eur. J. Cancer 40, 785–793 (2004).

  7. 7

    Weinstein, J.N. et al. Science 275, 343–349 (1997).

  8. 8

    Weinstein, J.N. & Pommier, Y. C R Biol. 326, 909–920 (2003).

  9. 9

    Shoemaker, R.H. Nat. Rev. Cancer 6, 813–823 (2006).

  10. 10

    Scherf, U. et al. Nat. Genet. 24, 236–244 (2000).

  11. 11

    Zhou, Y. et al. Cancer Research 62, 1688–1695 (2002).

  12. 12

    Scherf, U. et al. Nat. Genet. 24, 236–244 (2000).

  13. 13

    Staunton, J.E. et al. Proc. Natl. Acad. Sci. USA 98, 10787–10792 (2001).

  14. 14

    Tolliday, N. et al. Cancer Res. 66, 8935–8942 (2006).

  15. 15

    Weinstein, J.N. Mol. Cancer Ther., in the press.

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