B-cell lines that hypermutate their immunoglobulin genes can be exploited to generate antigen-specific antibodies.
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Presta, L. Celebrating diversity and mimicking maturation. Nat Biotechnol 20, 1096–1097 (2002). https://doi.org/10.1038/nbt1102-1096
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DOI: https://doi.org/10.1038/nbt1102-1096