Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

No free energy lunch

Nature Biotechnology volume 25, pages 1109–1110 (2007)Cite this article

Prediction of a protein's affinity for a ligand has been improved through fundamental physical modeling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Debit and credit in the hydrogen-bond economy.

References

  1. Lippow, S.M., Wittrup, K.D. & Tidor, B. Nat. Biotechnol. 25, 1171–1176 (2007).

    Article  CAS  Google Scholar 

  2. Chang, C.E. & Gilson, M.K. J. Am. Chem. Soc. 126, 13156–13164 (2004).

    Article  CAS  Google Scholar 

  3. Woo, H.J. & Roux, B. Proc. Natl. Acad. Sci. USA 102, 6825–6830 (2005).

    Article  CAS  Google Scholar 

  4. Mobley, D.L. et al. J. Mol. Biol. 371, 1118–1134 (2007).

    Article  CAS  Google Scholar 

  5. Tirado-Rives, J. & Jorgensen, W.L. J. Med. Chem. 49, 5880–5884 (2006).

    Article  CAS  Google Scholar 

  6. van Gunsteren, W.F. & Berendsen, H.J.C. Angew. Chem. Int. Ed. Engl. 29, 992–1023 (1990).

    Article  Google Scholar 

  7. Matthews, B.W. Annu. Rev. Biochem. 62, 139–160 (1993).

    Article  CAS  Google Scholar 

  8. Li, S. et al. Cancer cell 7, 301–311 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brian K. Shoichet is in the Dept. of Pharmaceutical Chemistry, University of California, San Francisco, 1700 4th Street, Suite 508D, San Francisco, California 94158-2330, USA. shoichet@cgl.ucsf.edu,

    Brian K Shoichet

Authors
  1. Brian K Shoichet
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shoichet, B. No free energy lunch. Nat Biotechnol 25, 1109–1110 (2007). https://doi.org/10.1038/nbt1007-1109

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1007-1109

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing