Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Antibodies in the breakdown lane

Nature Biotechnology volume 23, pages 1232–1234 (2005)Cite this article

An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: FcRn normally protects IgG from degradation by diverting endogenous IgG from lysosomes.

Bob Crimi

References

  1. Vaccaro, C. et al. Nat. Biotechnol. 23, 1283–1288 (2005).

    Article  CAS  Google Scholar 

  2. Junghans, R.P. Immunol. Res. 16, 29–57 (1997).

    Article  CAS  Google Scholar 

  3. Martin, W.L., West, A.P. Jr., Gan, L. & Bjorkman, P.J. Molec. Cell. 7, 867–877 (2001).

    Article  CAS  Google Scholar 

  4. Bitonti, A.J. et al. Proc. Natl. Acad. Sci. USA 101, 9763–9768 (2004).

    Article  CAS  Google Scholar 

  5. Hinton, P.R. et al. J. Biol. Chem. 279, 6213–6216 (2004).

    Article  CAS  Google Scholar 

  6. Akilesh, S. et al. J. Clin. Invest. 113, 1328–1333 (2004).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Liu, Z. et al. J. Exp. Med. 186, 777–783 (1997).

    Article  CAS  Google Scholar 

  8. Jin, F. & Balthasar, J.P. Hum. Immunol. 66, 403–410 (2005).

    Article  CAS  Google Scholar 

  9. Dall' Acqua, W.F. et al. J. Immunol. 169, 5171–5180 (2002).

    Article  Google Scholar 

  10. Ghetie, V. et al. Nat. Biotechnol. 15, 637–640 (1997).

    Article  CAS  Google Scholar 

  11. Samuelsson, A., Towers, T.L. & Ravetch, J.V. Science 291, 484–486 (2001).

    Article  CAS  Google Scholar 

  12. Getman, K.E. & Balthasar, J.P. J. Pharm. Sci. 94, 718–729 (2005).

    Article  CAS  Google Scholar 

  13. Roopenian, D.C. et al. J. Immunol. 170, 3528–3533 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, 02115, Massachusetts, USA

    Richard S Blumberg

  2. Children's Hospital Medical Center and Harvard Medical School, 300 Longwood Avenue, Boston, 02115, USA, Massachusetts

    Wayne I Lencer

Authors
  1. Richard S Blumberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wayne I Lencer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blumberg, R., Lencer, W. Antibodies in the breakdown lane. Nat Biotechnol 23, 1232–1234 (2005). https://doi.org/10.1038/nbt1005-1232

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt1005-1232

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing