In this issue, Bishop and colleagues present the third in a series of pig cloning reports using somatic cell nuclear transfer (see p. 1055). Nuclei were harvested from porcine fetal cells that had been cultured up to 87 days and passed as many as seven times, without visible signs of senescence. Nuclei were injected into oocytes that had been artificially activated by treatment with ionomycin. The method yielded four healthy piglets in two litters. The use of an in vitro system for culturing the donor cells may offer advantages over previously reported methods for scaling up pig cloning for breeding programs or making transgenics for xenografting.