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Goodbye Columbus! New NRDOs forego discovery

Companies that eschew drug discovery in favor of in-licensing have captured a lot of attention and investment over the past few years. But are these young companies really chasing a sustainable business model?

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Figure 1: Deal terms are rising over time for all stages of drug development.

Bob Crimi

References

  1. Sampaio, E.P. et al. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J. Exp. Med. 173, 699–703 (1991).

    Article  CAS  Google Scholar 

  2. Singhal, S. et al. Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. 341, 1565–1571 (1999).

    Article  CAS  Google Scholar 

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Thiel, K. Goodbye Columbus! New NRDOs forego discovery. Nat Biotechnol 22, 1087–1092 (2004). https://doi.org/10.1038/nbt0904-1087

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