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References

  1. 1

    Fernández, A. & Scheraga, H.A. Proc. Natl. Acad. Sci. USA 100, 113–118 (2003).

  2. 2

    Fernández, A. & Berry, R.S. Proc. Natl. Acad. Sci. USA 100, 2391–2396 (2003).

  3. 3

    Fernández, A., Kardos, J., Scott, R.L., Goto, Y. & Berry, R.S. Proc. Natl. Acad. Sci. USA 100, 6446–6451 (2003).

  4. 4

    Fernández, A., Scott, R.L. & Berry, R.S. Proc. Natl. Acad. Sci. USA 101, 2823–2827 (2004).

  5. 5

    Fernández, A., Sosnick, T.R. & Colubri, A.J. Mol. Biol. 321, 659–675 (2002).

  6. 6

    Fändrich, M. & Dobson, C.M. EMBO J. 21, 5682–5690 (2002).

  7. 7

    Fernández, A. & Scott, R.L. Phys. Rev. Lett. 91, 18102–18106 (2003).

  8. 8

    Ball, P. Nature 423, 25–26 (2003).

  9. 9

    Lum, K., Chandler, D. & Weeks, J.D. J. Phys. Chem. B 103, 4570–4577 (1999).

  10. 10

    Hummer, G., Rasaiah, J.C. & Noworyta, J.P. Nature 414, 188–190 (2002).

  11. 11

    Fernández, A. J. Chem. Phys. 119, 5315–5319 (2003).

  12. 12

    Roseman, M.A. J. Mol. Biol. 201, 621–624 (1988).

  13. 13

    Fernández, A. & Scott, R.L. Biophys. J. 85, 1914–1928 (2003).

  14. 14

    Carey, C., Cheng, Y.-K. & Rossky, P. Chem. Phys. 258, 415–425 (2000).

  15. 15

    Goldberg, M. & Gomez-Orellana, I. Nat. Rev. Drug Discov. 2, 289–295 (2003).

  16. 16

    Leone-Bay, A. et al. Pharm. Res. 18, 964–970 (2001).

  17. 17

    Unson, C.G. & Merrifield, R.B. Proc. Natl. Acad. Sci. USA 91, 454–458 (1994).

  18. 18

    Dobbs, R. et al. Science 187, 544–547 (1975).

  19. 19

    Sapse, A.M., Rothchild, R., Jain, D.C. & Unson, C.G. Mol. Med. 8, 251–262 (2002).

  20. 20

    Fernández, A., Scott, R.L. & Scheraga, H.A. J. Phys. Chem. B 107, 9929–9932 (2003).

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Acknowledgements

This research was supported in part by an unrestricted grant from Eli Lilly and Company. The work was motivated by conversations with Richard DiMarchi.

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Further reading

Figure 1: Wrapping of the glucagon molecule in helical conformation (PDB entry 1GCN).
Figure 2: Time dependence of the adsorption uptake and desorption of soluble mutants of the G4V glucagon peptide onto and from a dilauryl phosphatidylcholine bilayer coating a biosensing optical device.

Bob Crimi