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Specificity by design

The specificity of a homing endonuclease has been altered using computational modeling of the protein-DNA interface.

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Figure 1: Studies of the homing endonuclease I-MsoI (ref. 1) used detailed atomic level modeling to retarget the protein to an altered DNA site.

Katie Ris


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Pabo, C. Specificity by design. Nat Biotechnol 24, 954–955 (2006).

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