A variation on an approach that uses diphtheria toxin to ablate specific cells in mice provides a better means of assessing biological function.
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The online version of the original article can be found at 10.1038/90765
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Palmiter, R. Interrogation by toxin. Nat Biotechnol 19, 731–732 (2001). https://doi.org/10.1038/90770
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DOI: https://doi.org/10.1038/90770