Membrane-Based Affinity Technology for Commercial Scale Purifications

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Baum, R.M. 1987. Biotech industry moving pharmaceutical products to market. Chemical and Engineering News 65:11.

    Google Scholar 

  2. 2

    Biotechnology growing greener at last. 1987. Chemical Week 141:20.

  3. 3

    Affinity Chromatography and Biological Recognition. 1983. I. M. Chaiken, M.Wilchek, and I.Parikh (eds.). Academic Press, New York.

  4. 4

    Hill, E.A., and Hirtenstein, M.D. 1983. Affinity chromatography: its application to industrial scale processes, pp. 31–66 in Advances in Biotechnological Processes. Alan R. Liss, Inc., New York.

    Google Scholar 

  5. 5

    Bailon, P., Weber, D.V., Keeney, R.F., Fredericks, J.E., Smith, C., Familletti, P.C., and Smart, J.E. 1987. Receptor-affinity chromatography: a one-step purification for recombinant interleu-kin-2. Bio/Technology 5:1195.

    CAS  Google Scholar 

  6. 6

    Arnold, F.H., Chalmers, J.J., Saunders, M.S., Croughan, M.S., Blanch, H.W., and Wilke, C.R. 1985. A rational approach to the scale-up of affinity chromatography, pp. 113–122 in Purification of Fermentation Products. D. LeRoith, J. Shiloach, and T. J. Leahy (eds.). American Chemical Society, Washington, DC.

    Google Scholar 

  7. 7

    Clonis, Y.D. 1987. Large-scale affinity chromatography. Bio/Technology 5:1290.

    CAS  Google Scholar 

  8. 8

    Kessler, S.B., Zale, S.E., and Bratzler, R.L. 1987. Affinity device designs for process scale applications. Presented at the Society for Industrial Microbiology Annual Meeting, Baltimore, MD.

  9. 9

    Boucher, D.F., and Alves, G.E. 1959. Dimensionless numbers. Chem. Eng. Progress 55:55.

    CAS  Google Scholar 

  10. 10

    Olson, W.C., and Yarmush, M.L. 1987. Electrophoretic elution from monoclonal antibody immunoadsorbents: A theoretical and experimental investigation of controlling parameters. Biotech. Progress 3:177.

    CAS  Article  Google Scholar 

  11. 11

    Miekka, S.I., Ingham, K.C., and Menache, D. 1982. Rapid methods for isolation of human plasma fibronectin. Thromb. Res. 27:1.

    CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brandt, S., Goffe, R., Kessler, S. et al. Membrane-Based Affinity Technology for Commercial Scale Purifications. Nat Biotechnol 6, 779–782 (1988).

Download citation

Further reading


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing