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Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response

Nature Biotechnology volume 27, pages 604–605 (2009)Cite this article

To the Editor:

A study by Chechik et al.1 in the November issue examines the dynamic nature of the Saccharomyces cerevisiae transcriptional network through expression analyses and provides insights into the timing of mRNA transcription and degradation. Chechik et al. reported that selected S. cerevisiae metabolic genes form an 'activity motif'1, a genetic control-unit that allows a timed expression-regulation of a functional part of the metabolic network. This activity motif is induced at the mRNA and protein levels in response to several perturbations, including oxidant and heat exposure, and its activation ensures the required increase in NADPH regeneration1.

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Figure 1: Timing the metabolic reconfiguration of the antioxidant response.

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Acknowledgements

We are grateful to B. Timmermann and S. Krobitsch (MPI-MG) for providing materials and to M. Gibson (University of Pittsburgh Medical Center) for critical reading of the manuscript. Part of this work was funded by the Max Planck Society.

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Authors and Affiliations

  1. Max Planck Institute for Molecular Genetics, Berlin, Germany

    Markus Ralser, Simone Latkolik & Hans Lehrach

  2. Metabolic Unit, VU University Medical Center Amsterdam, Amsterdam, The Netherlands

    Mirjam M C Wamelink, Erwin E W Jansen & Cornelis Jakobs

Authors
  1. Markus Ralser
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  2. Simone Latkolik
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  3. Erwin E W Jansen
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  4. Hans Lehrach
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  5. Cornelis Jakobs
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Ralser, M., Wamelink, M., Latkolik, S. et al. Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response. Nat Biotechnol 27, 604–605 (2009). https://doi.org/10.1038/nbt0709-604

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