Abstract
Matrix metalloproteinase inhibitors will be approved as drugs, probably this year, but questions remain concerning their specificity, bioavailability, and potential long-term toxicity
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gearing, A.J.H., et al. 1994. Processing of tumour necrosis factor—A precursor by metalloproteinases. Nature 370: 555–557.
Mohler, K.M., et al. 1994. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing, Nature 370: 218–220.
Murphy, G. and Docherty, A.J.P. 1992. The Matrix metalloproteainases and their inhibitors. Am. J. Respir. Cell Mol. Biol. 7: 120–125.
Docherty, A.J.P., et al. 1992. The matrix metalloproteinases and their natural inhibitors: Prospects for treating degenerative tissue disease. TIBETECH 10: 200–207.
Sato, H., et al. 1994. A matrix metalloproteinase expressed on flie surface of invasive tumour cells. Nature 370: 61–65,
Taraboletti, G., et al. 1995. Inhibition of aogiogenesis and murine hemangioma growth by Batimastat, a synthetic inhibitor of matrix metalloproteuiases. NCI 87: 293–298.
Golub, L.M., et al. 1991. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit. Rev. Oral. Biol. Med. 2: 297–322.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hodgson, J. Remodeling MMPIs. Nat Biotechnol 13, 554–557 (1995). https://doi.org/10.1038/nbt0695-554
Issue Date:
DOI: https://doi.org/10.1038/nbt0695-554
This article is cited by
-
Design, synthesis and evaluation of 6-oxo-1, 6-dihydropyrimidine-2,5-dicarboxamide derivatives as MMP 13 inhibitors
Chemical Research in Chinese Universities (2013)
-
Design and Synthesis of a Peptidyl-FRET Substrate for Tumor Marker Enzyme human Matrix Metalloprotease-2 (hMMP-2)
International Journal of Peptide Research and Therapeutics (2012)
